1,2-Bis[(Dimethylamino)Dimethylsilyl]Ethane[Protectingreagentforaromaticprimaryamines]

Catalog Number	ACM91166506-3
CAS Number	91166-50-6
Structure
Synonyms	Ethane-1,2-Diylbis(N,N,1,1-Tetramethylsilanamine)Silanamine,1,1-(1,2-Ethanediyl)Bis[N,N,1,1-Tetramethyl-
Molecular Weight	232.51 g/mol
Molecular Formula	C10H28N2Si2
Application	12-Bis[(Dimethylamino)Dimethylsilyl]Ethane serves as an effective protecting reagent for aromatic primary amines particularly suited for those with pKa values between 10 and 11 such as substituted anilines It facilitates the preparation of Stabase derivatives by reacting equimolar amounts of the compound and anilines with zinc iodide under nitrogen at 140°C This method not only enables the protection of the amines but also allows for straightforward purification of the products often via vacuum distillation The Stabase adduct is advantageous as a protecting group offering ease of preparation stability under basic conditions and easy removal in ether with methanol and p-toluenesulfonic acid

Custom Reviews

November 14, 2024

Efficient Protecting Reagent for Aromatic Primary Amines

Using Alfa Chemistry's 1,2-Bis[(Dimethylamino)Dimethylsilyl]Ethane, I achieved excellent protection of substituted anilines. Its straightforward application and reliable results in my research were impressive. Highly recommend for lab use!

※ Please kindly noted that this product is for research use only.