1,3-Dichlorotetraisopropyldisiloxane

Catalog Number	ACM69304376-2
CAS Number	69304-37-6
Molecular Weight	315.43 g/mol
Molecular Formula	C12H28Cl2OSi2
Boiling Point	120 °C(15mm
Flash Point	>110 °C
Purity	0.95
Density	0.986 g/mL
Application	13-Dichlorotetraisopropyldisiloxane is a versatile silylating reagent primarily used for the simultaneous protection of the 3’- and 5’-hydroxyl groups in ribonucleosides This compound plays a critical role in the analysis of Watson-Crick and Hoogsteen base pairing within nucleotides and contributes to the development of ribavirin chemical delivery systems Its utility extends to serving as a protecting group for carbohydrates and open-chain polyhydroxy compounds Additionally it is instrumental in the synthesis of cyclic bridged peptides The design of this reagent takes advantage of the fact that triisopropylsilyl chloride reacts significantly faster with primary alcohols compared to secondary alcohols This reactivity is harnessed to achieve initial silylation at the 5’-position of 3’5’-dihydroxy nucleosides leading to an intramolecular reaction with the secondary alcohol at the 3’-position thereby providing a doubly protected derivative

Custom Reviews

November 16, 2024

Highly Effective Silylating Agent for Research

Using 1,3-Dichlorotetraisopropyldisiloxane from Alfa Chemistry significantly enhanced our nucleotide base pairing analyses. This reagent provided reliable protection for hydroxyl functions, streamlining our research processes effectively.

※ Please kindly noted that this product is for research use only.