Bis(Dimethylaminodimethylsilyl)Ethane

Catalog Number	ACM91166506-4
CAS Number	91166-50-6
Structure
Molecular Weight	232.51 g/mol
Molecular Formula	C10H28N2Si2
Boiling Point	221.7 °C(760 mmHg)
Flash Point	87.9 °C
Density	0.831 g/mL
Application	Bis(Dimethylaminodimethylsilyl)Ethane is a versatile reagent primarily used for the protection of primary aromatic amines specifically those with pKa values ranging from 10 to 11 such as substituted anilines It facilitates the formation of stable Stabase derivatives where protection is achieved by reacting equimolar amounts of the compound with the amines in the presence of zinc iodide under nitrogen at elevated temperatures This process is particularly notable for its efficiency and the ability to purify the resulting products by vacuum distillation Furthermore the cleavage of these protective groups back to primary amines is simple requiring only the presence of methanol and a small amount of acid in an ether solution The Stabase adducts formed are not only easy to prepare but also stable and can be readily removed making Bis(Dimethylaminodimethylsilyl)Ethane a preferred choice for chemists seeking a robust and reversible amine protection strategy

Custom Reviews

November 27, 2024

Reliable Reagent for Amines Protection

I used Bis(Dimethylaminodimethylsilyl)Ethane in my research for protecting primary aromatic amines. Its efficiency in forming stable Stabase adducts is impressive, especially with lower pKa substrates. A user-friendly and effective solution!

※ Please kindly noted that this product is for research use only.