| Catalog Number |
ACM7751384-2 |
| CAS Number |
7751-38-4 |
| Structure |
 |
| Synonyms |
Dichlorodiisopropylsilane, Dichloro[Bis(1-Methylethyl)]Silane |
| IUPAC Name |
dichloro-di(propan-2-yl)silane |
| Molecular Weight |
185.17 g/mol |
| Molecular Formula |
C6H14Cl2Si |
| Canonical SMILES |
CC(C)[Si](C(C)C)(Cl)Cl |
| InChI Key |
GSENNYNYEKCQGA-UHFFFAOYSA-N |
| Boiling Point |
64-65/25 |
| Melting Point |
<0 °C |
| Flash Point |
43°C |
| Purity |
0.97 |
| Density |
1.026 g/mL |
| Appearance |
Straw amber liquid |
| Application |
Dichlorodiisopropylsilane is a valuable component in nucleoside 3',5'-hydroxy protection and can be utilized in the Peterson alkenation reaction. The use of silicon groups as protection for hydroxy groups is a well-known technique. One effective method is to utilize a protecting group that covers both the 3- and 5-hydroxy groups of a nucleoside, such as the diisopropylsilyl group. By reacting the nucleoside with dichlorodiisopropylsilane and imidazole in DMF, the nucleoside can be effectively protected. Although the tetraisopropyldisiloxy group is more common for 3',5'-hydroxy-bridging protection, the use of diisopropyldichlorosilane provides an alternative and potentially useful approach in nucleoside protection. |
| Storage |
Storage conditions: Keep container tightly closed. Keep in a cool place. Store locked up. |
| Chemical Formula |
C6H14Cl2Si |
| Exact Mass |
184.02400 |
| Refractive Index |
1.4450 |
