NO-Bis(Trimethylsilyl)Trifluoroacetamide 98% J&Kseal serves as a versatile silylation reagent utilized for the derivatization of a wide array of functional groups including carboxylic acids phenols steroids amines alcohols alkaloids and amides Its applications extend to the synthesis of pharmaceutical intermediates and the preparation of pyrimidinone ribosides and analogs with anti-tumor properties Recognized for its efficiency in gas chromatography (GC) and mass spectrometry (MS) this compound is often favored over similar reagents such as BSA due to superior product stability and yield Additionally it sees use in contemporary research areas like metabolomics where it aids in analyzing psychoactive amines in khat and measuring acrylamide in cocoa Moreover it plays a role in analytical techniques such as HPLC-electrochemical detection assays for compounds like 8-oxo-deoxyguanosine and 8-oxo-guanine highlighting its significance in both basic and applied chemical research
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