CAS 18162-48-6 T-Butyldimethylchlorosilane, 98% - Organosilicon / Alfa Chemistry

Catalog Number	ACM18162486-7
CAS Number	18162-48-6
Structure
Molecular Weight	150.75 g/mol
Molecular Formula	C6H15ClSi
Boiling Point	124 °C-126 °C
Melting Point	87.00 °C-90.00 °C
Flash Point	22.00 °C
Density	0.830 g/mL
Application	T-Butyldimethylchlorosilane 98% is primarily used in organic synthesis to protect hydroxyl groups It is instrumental in creating complex molecules such as prostaglandins and serves as a crucial auxiliary in producing hypolipidemic agents like lovastatin and simvastatin Additionally it facilitates the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes This compound acts as a versatile protecting agent for various functional groups including amines amides and alcohols and is widely used in the synthesis of pharmaceuticals It is particularly effective as a protective group for hydroxyls in ribonucleoside synthesis and also functions as an oxidant and decyanide agent T-Butyldimethylchlorosilane is a highly useful anion trapping reagent efficiently capturing different anions to form stable silyl compounds For instance it can trap lithio α-phenylthiocyclopropane anions and facilitate the creation of CN-disilyl- and N-silylketenimines in high yields by reacting with lithium anions of nitriles The compound also aids in synthesizing silyl stannanes which when treated with alkynes and catalytic tetrakis(triphenylphosphine)palladium(0) yield cis-silyl stannylalkenes effectively

Catalog Number

ACM18162486-7

CAS Number

18162-48-6

Structure

Molecular Weight

150.75 g/mol

Molecular Formula

C6H15ClSi

Boiling Point

124 °C-126 °C

Melting Point

87.00 °C-90.00 °C

Flash Point

22.00 °C

Density

0.830 g/mL

Application

T-Butyldimethylchlorosilane 98% is primarily used in organic synthesis to protect hydroxyl groups It is instrumental in creating complex molecules such as prostaglandins and serves as a crucial auxiliary in producing hypolipidemic agents like lovastatin and simvastatin Additionally it facilitates the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes This compound acts as a versatile protecting agent for various functional groups including amines amides and alcohols and is widely used in the synthesis of pharmaceuticals It is particularly effective as a protective group for hydroxyls in ribonucleoside synthesis and also functions as an oxidant and decyanide agent T-Butyldimethylchlorosilane is a highly useful anion trapping reagent efficiently capturing different anions to form stable silyl compounds For instance it can trap lithio α-phenylthiocyclopropane anions and facilitate the creation of CN-disilyl- and N-silylketenimines in high yields by reacting with lithium anions of nitriles The compound also aids in synthesizing silyl stannanes which when treated with alkynes and catalytic tetrakis(triphenylphosphine)palladium(0) yield cis-silyl stannylalkenes effectively

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