The rapid development of biomedicine has brought great benefits to human health and social development. Due to good biocompatibility, anticoagulation, non-toxic, colorless, tasteless, high and low temperature resistance, oxidation resistance, stable physical and chemical properties and many other outstanding advantages, organosilicon products have been successfully used in the field of medicine in all aspects after decades of development. Among them, the silicone (also known as polysiloxane) is the most used organosilicon products in the field of medicine. Silicone generally includes three categories of silicone rubber, silicone oil and silicone resin.
The application of organosilicon products in the field of medicine can be divided into the following aspects:
As a component of pharmaceutical formulation: Silicone oil can be used as an excipient or additive in the formulation of dermatological drugs to assist in the treatment of various skin diseases, such as acne, psoriasis, fungal dermatitis, eczema, skin burns, etc. Usually, silicon-based excipients can improve the bioavailability of the active drug, the aesthetics and the processability of topical pharmaceutical formulations (creams, emulsions, gels, ointments, lotions, sprays and stick formulations).
Pharmaceutical synthesis: First of all, silylating reagent as a group protective agent can protect the active hydrogen in the pharmaceutical synthesis reactions, greatly improving the quality of drugs and decreasing the production cycle of drugs. At present, silylating reagents have been successfully used in the pharmaceutical industry, and common silylating reagents are dimethyldichlorosilane, trimethylchlorosilane, hexamethyldisilane, etc. Secondly, the different spatial and substitutional structures of organosilicon compounds provide the possibility to regulate and improve the stability, solubility and pharmacokinetic properties of the drugs. At present, many methods can be used to directly prepare drugs containing silicon and its derivatives.
Medical defoaming agent: Medical silicone defoaming agent can be made by the reactant of polydimethylsiloxane and gaseous silica. Silicone defoaming agent can eliminate a large amount of foam on the visual field of gastroscopy lens and makes the examination more convenient and accurate. It can also be combined with stomach disease treatment drugs to eliminate the patient's gastrointestinal flatulence, relieve acid reflux and abdominal distension and other symptoms, which is be beneficial for the treatment of peptic ulcer, reflux esophagitis and other diseases. In addition, it can be used in the treatment of acute pulmonary edema, which can quickly dredge the respiratory tract, improve hypoxia, reduce or avoid asphyxia due to the end of the bubble blocks airflow.
Drug-sustained release: Silicone rubber can be used as drug sustained-release material. The preparation methods of the sustained-release system are mainly as follows: one is to control the release of drug by coating it in a silicone rubber film; The other is to evenly distribute the drug directly in the silicone rubber matrix. These two preparation methods can effectively control the drug release and make the drug exert its effect for a long time.
Others: Silicone rubber can also be used in medical catheter, stent and stent coating, oral materials, artificial organs and tissues, medical electrodes, biosensors and so on. Silane coupling agent contains amino group, sulfhydryl group, epoxy group and other active groups, which can bond with biomolecule. Therefore, it has a good application prospect in the fields of enzyme immobilization, molecular biology, cell biology, affinity chromatography and other fields.
What can we do?
Alfa Chemistry has many years of research strength in the field of organosilicon applications and is committed to promoting the further application of organosilicon in the field of medicine. We can provide customers with a variety of organosilicon materials and related technical support and services for medicine research. Today, we have served many companies and organizations in the medicine industry, and our high-quality products and technical services bring great benefits to them. If you require any assistance, please contact us and our team will provide you with fullest support at the most abundant experience and the most affordable price.