N-(Methoxymethyl)-N-(Trimethylsilylmethyl)Benzylamine

Catalog Number	ACM93102057-1
CAS Number	93102-05-7
Structure
Molecular Weight	237.41 g/mol
Molecular Formula	C13H23NOSi
Boiling Point	76 °C(0.3 mmHg)
Flash Point	66 °C
Purity	~90%
Density	0.928-0.936 g/mL
Appearance	Colorless to light yellow clear liquid
Application	N-(Methoxymethyl)-N-(Trimethylsilylmethyl)Benzylamine serves as a critical reagent in the synthesis of N-benzyl substituted pyrrolidines through [3+2] cycloaddition reactions with αβ-unsaturated esters This reagent is highly valued for its ability to generate N-benzyl azomethine ylide in situ utilizing catalysts such as trifluoroacetic acid for efficient reactivity N-(Methoxymethyl)-N-(Trimethylsilylmethyl)Benzylamine is preferred for its ease of handling compared to alternative silylmethylamine precursors The reactive intermediate produced in this process acts as a 13-dipolar species facilitating reactions with electron-deficient alkenes and alkynes to form pyrrolidine derivatives 3-pyrrolines and pyrroles The specificity of cycloaddition ensuring complete cis stereospecificity contributes to convergent pathways in forming diverse pyrrolidine structures This reagent is particularly significant in large-scale practical syntheses of chiral pyrrolidines and 3-carboxy-1-azabicyclo[221]heptane derivatives which are notable for their physiological activity
Storage	Keep in dark place,Sealed in dry,Room Temperature
Hazardous Materials Information	Not hazardous material
MDL Number	MFCD00674005
Packaging	1 g

Custom Reviews

November 03, 2024

Efficient and Versatile Reagent for Pyrrolidine Synthesis

After using N-(Methoxymethyl)-N-(Trimethylsilylmethyl)Benzylamine from Alfa Chemistry, I found it easy to handle and effective in synthesizing pyrrolidines via [3+2] cycloaddition for my research. Highly recommended for precision in chemical synthesis.

※  Please kindly noted that this product is for research use only.

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