N-Methoxymethyl-N-(Trimethylsilylmethyl)Benzylamine, 94%

Catalog Number	ACM93102057-5
CAS Number	93102-05-7
Structure
Molecular Formula	C13H23NOSi
Boiling Point	76 °C(0.3 mmHg)
Flash Point	66 °C
Density	0.928 g/mL
Application	N-Methoxymethyl-N-(Trimethylsilylmethyl)Benzylamine 94% serves a crucial role as a reagent in the synthesis of N-benzyl substituted pyrrolidines through [3+2] cycloaddition with αß-unsaturated esters This compound is preferred for the generation of N-benzyl azomethine ylides due to its ease of handling and effectiveness over other silylmethylamine precursors These ylides produced conveniently using trifluoroacetic acid or alternative catalysts like LiF and TBAF act as 13-dipolar species facilitating efficient reactions with alkenes and alkynes to yield pyrrolidine derivatives and 3-pyrrolines respectively The process favors electron-deficient partners promoting reactions with unsaturated esters and other suitable dipolarophiles and providing a streamlined route to chiral pyrrolidines vital in producing physiological active compounds such as 3-carboxy-1-azabicyclo[221]heptane derivatives The reaction exhibits complete cis stereospecificity offering access to both fused bicyclic and spirocyclic systems depending on the dipolarophile involved
Storage	Moisture Sensitive
HS Code	Non-hazardous for shipping
MDL Number	MFCD00674005
Refractive Index	1.492