(Chloromethyl) Dimethyl(Phenyl)Silane

Catalog Number	ACM1833518-3
CAS Number	1833-51-8
Structure
Synonyms	(Chloromethyl) Dimethyl(Phenyl)silane
Molecular Weight	184.74 g/mol
Molecular Formula	C9H13ClSi
Purity	0.95
Appearance	Clolorless liquid
Application	(Chloromethyl) Dimethyl(Phenyl)Silane serves multiple purposes in chemical synthesis primarily as a starting material for the creation of Grignard reagents It is also employed in heteroatom and carbon alkylation processes facilitating the production of various organometallic and organolanthanide compounds One of its notable advantages compared to similar compounds is its ability to undergo Fleming oxidation which effectively turns it into a masked hydroxyl group This capability makes it highly valuable in the synthesis of both C-substituted and N-substituted compounds Additionally (Chloromethyl) Dimethyl(Phenyl)Silane acts as a precursor for (phenyldimethylsilyl)methoxymethyl chloride (SMOM-Cl) a compound used as a hydroxyl protecting group It can specifically introduce a silylmethyl group onto carbon through C-alkylation of various substrates such as terminal alkynes dihydropyrazines and imines However its tendency to undergo rearrangements under certain conditions poses a disadvantage that must be managed during its use For some reactions converting it to the corresponding iodide via Finkelstein displacement before proceeding with alkylation can be beneficial often requiring strong bases and controlled temperatures to achieve optimal results

Custom Reviews

November 24, 2024

Versatile Reagent for Alkylation in Organic Synthesis

I've been using (Chloromethyl) Dimethyl(Phenyl)Silane from Alfa Chemistry in research. It effectively serves as a precursor for organometallic reagents. Its ability for heteroatom alkylation significantly aided my synthesis work.

※  Please kindly noted that this product is for research use only.

1,1,3,3-Tetrachloro-1,3-Disilabutane (148859-49-8)

Phenyltrifluorosilane (368-47-8)

3-(Tert-Butyldimethylsilyloxy)Glutaric Anhydride (91424-40-7)

Di-Tert-Butylchlorosilane (56310-18-0)

3,5-Bis(Trifluoromethyl)Phenyldimethylchlorosilane (732306-23-9)

((3,5-Dichloro-4-(3-Isopropyl-4-Methoxyphenoxy)Phenyl)Ethynyl)Trimethylsilane (525575-59-1)