(Trifluoromethyl)Trimethylsilane [Trifluoromethylating Reagent]

Catalog Number	ACM81290202-4
CAS Number	81290-20-2
Structure
Synonyms	(Trimethylsilyl)trifluoromethane; Ruppert-Prakash Reagent
Molecular Weight	142.2
Molecular Formula	C4H9F3Si
Boiling Point	55 °C
Flash Point	-32 °C
Purity	>97%
Appearance	Colorless to light yellow clear liquid
Application	(Triuoromethyl)Trimethylsilane (TMSCF3) is a versatile trifluoromethylating reagent that is commonly used in nucleophilic addition reactions of aldehydes and ketones. It was first synthesized by Rupert in 1984 and has since become an important tool in various chemical reactions, such as transition-metal-catalyzed reactions and addition to carbonyl and imine groups. These reactions are valuable in industries like pharmaceuticals and agrochemicals as they enhance metabolic stability and alter compound properties. TMSCF3 is also known as the Ruppert-Prakash fluorination reagent and is widely used for the synthesis of trifluoromethyl-containing compounds.
Storage	Store under inert gas
MDL Number	MFCD00145454
Reaxys Registry Number	4241868
Specific Gravity	0.96

Custom Reviews

2024-8-13

Enhancing Trifluoromethylation in Science Research with TMSCF3

As a researcher in the pharmaceutical industry, I have found great success using Trimethyl(trifluoromethyl)silane (TMSCF3) as a versatile reagent for trifluoromethylation reactions. This flammable colorless liquid has proven to be a valuable tool in nucleophilic addition reactions of aldehydes and ketones, as well as in transition-metal-catalyzed reactions and addition to carbonyl and imine groups. The use of TMSCF3 has significantly enhanced the metabolic stability and altered the properties of several compounds, making it an essential component in my research endeavors. Its efficient trifluoromethylation capabilities have truly elevated the quality of my work in the lab.

※  Please kindly noted that this product is for research use only.

1,1,3,3-Tetrachloro-1,3-Disilabutane (148859-49-8)

Phenyltrifluorosilane (368-47-8)

1-Bromo-3-(Tert-Butyldimethylsiloxy)Benzene (65423-56-5)

3,5-Bis(Trifluoromethyl)Phenyldimethylchlorosilane (732306-23-9)

3-(Tert-Butyldimethylsilyloxy)Glutaric Anhydride (91424-40-7)

(Dichloromethyl)Methyldichlorosilane (1558-31-2)